A new ionic model of the neuronal-membrane electrical activity has been developed. The proposed model generalizes those usually quoted in the literature, taking into account the significant ionic currents, the temperature dependence of the electrical parameters, and the stochastic synaptic inputs. The model allows us to simulate both the membrane Bring activity, as a function of the temperature, and the membrane resistance behavior, as a function of temperature and of intracellular calcium concentration. The I-V nonlinear characteristic, together with histograms and correlograms of the time intervals between spikes, have been numerically reproduced. Various comparisons we have carried out with available experimental data show a good theoretical-experimental agreement.
A generalized ionic model of the neuronal membrane electrical activity / P., Bernardi; D'Inzeo, Guglielmo; Pisa, Stefano. - In: IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING. - ISSN 0018-9294. - STAMPA. - (1994), pp. 125-133. [10.1109/10.284923]
A generalized ionic model of the neuronal membrane electrical activity
D'INZEO, Guglielmo;PISA, Stefano
1994
Abstract
A new ionic model of the neuronal-membrane electrical activity has been developed. The proposed model generalizes those usually quoted in the literature, taking into account the significant ionic currents, the temperature dependence of the electrical parameters, and the stochastic synaptic inputs. The model allows us to simulate both the membrane Bring activity, as a function of the temperature, and the membrane resistance behavior, as a function of temperature and of intracellular calcium concentration. The I-V nonlinear characteristic, together with histograms and correlograms of the time intervals between spikes, have been numerically reproduced. Various comparisons we have carried out with available experimental data show a good theoretical-experimental agreement.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
