The effects of hashish (HA) on an in vitro model (isolated guinea-pig ileum and rabbit jejunum) of acute dependence have been evaluated. HA reduced the the naloxone-induced contractions in both tissues. High doses of HA inhibited the spontaneous activity of rabbit jejunum; a similar inhibition is observed following administration od opioids. These results show that the antagonism of HA can be revealed also in the isolated gut tissues of naive animals.
HASHISH ANTAGONISM ON THE IN VITRO DEVELOPMENT OF WITHDRAWAL CONTRACTURE / L. A., Morrone; Romanelli, Luca; Mazzanti, Gabriela; Valeri, Pacifico; F., Menichini. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - STAMPA. - 27 Supplement 1:(1993), pp. 63-64. (Intervento presentato al convegno VI° Congress of the Italian Society of Pharmacognosy tenutosi a Roma (Italia) nel 9-12 Ottobre, 1991).
HASHISH ANTAGONISM ON THE IN VITRO DEVELOPMENT OF WITHDRAWAL CONTRACTURE
ROMANELLI, LUCA;MAZZANTI, Gabriela;VALERI, Pacifico;
1993
Abstract
The effects of hashish (HA) on an in vitro model (isolated guinea-pig ileum and rabbit jejunum) of acute dependence have been evaluated. HA reduced the the naloxone-induced contractions in both tissues. High doses of HA inhibited the spontaneous activity of rabbit jejunum; a similar inhibition is observed following administration od opioids. These results show that the antagonism of HA can be revealed also in the isolated gut tissues of naive animals.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
