The rabbit isolated urinary bladder contracted in the presence of Lys8-vasopressin from threshold concentrations of 5 to 30 μ ml−1 (0·02 to 0·11 ng ml−1). Responses were proportional to the dose used. The tissue gave satisfactory results either fresh or after storage for several days in cold Tyrode or Krebs solution (3–4°). The preparation also contracted in the presence of oxytocin, but it was 7 to 20 times less sensitive to this peptide. A number of other peptides and amines known to stimulate smooth muscle showed low activity on the rabbit urinary bladder and, occasionally, intense tachyphylaxis.
Bioassay of vasopressin on the rabbit isolated urinary bladder / L., Angelucci; G., Falconieri Erspamer; Negri, Lucia. - In: JOURNAL OF PHARMACY AND PHARMACOLOGY. - ISSN 0022-3573. - STAMPA. - 26:3(1974), pp. 193-196. [10.1111/j.2042-7158.1974.tb09253.x]
Bioassay of vasopressin on the rabbit isolated urinary bladder.
NEGRI, Lucia
1974
Abstract
The rabbit isolated urinary bladder contracted in the presence of Lys8-vasopressin from threshold concentrations of 5 to 30 μ ml−1 (0·02 to 0·11 ng ml−1). Responses were proportional to the dose used. The tissue gave satisfactory results either fresh or after storage for several days in cold Tyrode or Krebs solution (3–4°). The preparation also contracted in the presence of oxytocin, but it was 7 to 20 times less sensitive to this peptide. A number of other peptides and amines known to stimulate smooth muscle showed low activity on the rabbit urinary bladder and, occasionally, intense tachyphylaxis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
