Eledoisina Una sostanza farmacologica per la sindrome da disfunzione lacrimale - Review -

The dry eye or lachrymal dysfunction syndrome is a multifactorial disease and of the ocular surlace characterized by discomfort, visual disturbances, foreign body sensation and instability of the lachrymal film; its pathogenesis and linked to a reduction in the production of tears or to an increase in losses evaporative cooling. It is a very common disease, which affects about 33% in the general population. The progress made in the context of the study on the physiopathology of the dry eye have allowed us to develop, over the years, new therapeutic strategies. The eledoisin is the class of medicines secretagogues, used in dry eye syndrome. From a chemical point of view, the eledoisin is a polypeptide composed of 11 aminoacids with the following sequence: pGlu-Pro-Ser-Lys-Asp-AlaPhe-lle-Gly-Leu-Met-NH. It is a neuropeptide (a tachichinina already substance P) extracted trom salivary glands of some mollusks like Eledone Aldrovanti. Performs a series of regulatory activities district, between which the vasodilatation and contraction of smooth muscle thereby increasing the blood flow in the districts muscle and skin and is able to bind to beta adrenergic receptors. It is also assumed that the eledoisina will lead to a marked effect of stimulation of gland secretions lacrimal duct in patients with Sjogren's syndrome and slow fuction glands tear ducts