Rats were given a diet containing 10% (w/w) erucuc acid for 10 days while the control group received the standard diet. At the end of the treatment animals were anaesthetized and adrenaline was injected through the jugular vein until cardiac arrest. ECG was registered, pulmonary oedema was evidenced by haematic exudate flowing out of the tracheal cannula. Ventricular fibrillation, pulmonary oedema and cardiac arrest occurred significantly earlier in th erucic acid group than in the group on normal diet. The model described could be useful for the study of the drugs potentially active in major cardiac conditions, such as left ventricular failure.
Erucic acid induced myocardial steatosis in rats as a possible model of heart failure / R., Lisciani; S., Cozzolino; A., Mancini; G., Bellezza; G., Moscovicci; P., Benatti; Mazzanti, Gabriela; DE FEO, Giuseppe. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - STAMPA. - 21:5(1989), pp. 641-642. [10.1016/1043-6618(89)90211-9]
Erucic acid induced myocardial steatosis in rats as a possible model of heart failure
MAZZANTI, Gabriela;DE FEO, Giuseppe
1989
Abstract
Rats were given a diet containing 10% (w/w) erucuc acid for 10 days while the control group received the standard diet. At the end of the treatment animals were anaesthetized and adrenaline was injected through the jugular vein until cardiac arrest. ECG was registered, pulmonary oedema was evidenced by haematic exudate flowing out of the tracheal cannula. Ventricular fibrillation, pulmonary oedema and cardiac arrest occurred significantly earlier in th erucic acid group than in the group on normal diet. The model described could be useful for the study of the drugs potentially active in major cardiac conditions, such as left ventricular failure.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
