In an in vivo study of salivation in rats, the scialogogic effects of two natural and amphibian tachykinins, PG-SPI and PG-KII, which activate distinct tachykinin receptors, were compared with those of the tachykinins substance P, neurokinin A and B, and kassinin. The rank order of potencies of these peptides injected intravenously on salivation was: PG-SPI = SP greater than or equal to PG-KII = KASS > NKA >> NKB. Atropine (1 mg/kg, IV) had no effect on PG-SPI-, SP-, and NKA-induced salivation, but reduced that stimulated by PG-KII and KASS. We conclude that PG-SPI and PG-KII increase salivary secretion through different mechanisms and that rat salivary glands contain PG-SPI- and PG-KII-sensitive receptors.
Effect of PG-SPI and PG-KII, two novel and natural tachykinins, on salivary secretion in the rat / Broccardo, Maria; Improta, Giovanna; A., Brandoni; A., Tabacco. - In: PEPTIDES. - ISSN 0196-9781. - 17:4(1996), pp. 729-731. [10.1016/0196-9781(96)00052-6]
Effect of PG-SPI and PG-KII, two novel and natural tachykinins, on salivary secretion in the rat
BROCCARDO, Maria;IMPROTA, Giovanna;
1996
Abstract
In an in vivo study of salivation in rats, the scialogogic effects of two natural and amphibian tachykinins, PG-SPI and PG-KII, which activate distinct tachykinin receptors, were compared with those of the tachykinins substance P, neurokinin A and B, and kassinin. The rank order of potencies of these peptides injected intravenously on salivation was: PG-SPI = SP greater than or equal to PG-KII = KASS > NKA >> NKB. Atropine (1 mg/kg, IV) had no effect on PG-SPI-, SP-, and NKA-induced salivation, but reduced that stimulated by PG-KII and KASS. We conclude that PG-SPI and PG-KII increase salivary secretion through different mechanisms and that rat salivary glands contain PG-SPI- and PG-KII-sensitive receptors.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
