The natural heptapeptide D-Ala-deltorphin II, the most selective agonist for delta-receptors currently available, was used to study the role of brain delta-opioid receptors in the control of body temperature. In rats placed in a cold ambient temperature (4-degrees-C), intracerebroventricular injections of D-Ala-deltorphin II produced a significant hypothermia. In animals at an ambient temperature of 22-degrees-C, only the highest dose employed induced a slight fall in body temperature. At a warm temperature (34-degrees-C), D-Ala-deltorphin II induced no significant changes in body temperature. D-Ala-deltorphin II-induced hypothermia, unaffected by naloxone, was significantly reduced by the selective delta-receptor antagonist naltrindole. These findings indicate that D-Ala-deltorphin II produces its hypothermic effects at a supraspinal delta-receptor, and support the involvement of delta-receptors in central control of body temperature.

Hypothermic Effect of D-ala-deltorphin-ii, A Selective Delta-opioid Receptor Agonist / Broccardo, Maria; Improta, Giovanna. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 139(1992), pp. 209-212. [10.1016/0304-3940(92)90554-K]

Hypothermic Effect of D-ala-deltorphin-ii, A Selective Delta-opioid Receptor Agonist

BROCCARDO, Maria;IMPROTA, Giovanna
1992

Abstract

The natural heptapeptide D-Ala-deltorphin II, the most selective agonist for delta-receptors currently available, was used to study the role of brain delta-opioid receptors in the control of body temperature. In rats placed in a cold ambient temperature (4-degrees-C), intracerebroventricular injections of D-Ala-deltorphin II produced a significant hypothermia. In animals at an ambient temperature of 22-degrees-C, only the highest dose employed induced a slight fall in body temperature. At a warm temperature (34-degrees-C), D-Ala-deltorphin II induced no significant changes in body temperature. D-Ala-deltorphin II-induced hypothermia, unaffected by naloxone, was significantly reduced by the selective delta-receptor antagonist naltrindole. These findings indicate that D-Ala-deltorphin II produces its hypothermic effects at a supraspinal delta-receptor, and support the involvement of delta-receptors in central control of body temperature.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/462267
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