The present report examines the effect of different calcitonins and analogs on the in vitro phosphorylation of brain synaptic membrane proteins. The findings demonstrate that calcitonin is a potent inhibitor of several brain synaptic proteins and that salmon and eel calcitonins are considerably more potent than thyrocalcitonin in eliciting this effect. Deletion of leucine from position 16 in salmon calcitonin sequence resulted in a drastic loss of inhibitory activity, indicating the importance for a hydrophobic residue at position 16 in the intact calcitonin molecule. The mechanism of calcitonin inhibition of protein phosphorylation was likely due to the blockade of stimulation of protein kinases by calmodulin.

Calcitonin inhibits the phosphorylation of various proteins in rat brain synaptic membranes / Patel, J; Fabbri, A; Pert, C; Gnessi, Lucio; Fraioli, F; Mcdevitt, R.. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - STAMPA. - 130:(1985), pp. 669-676. [10.1016/0006-291X(85)90469-3]

Calcitonin inhibits the phosphorylation of various proteins in rat brain synaptic membranes.

GNESSI, Lucio;
1985

Abstract

The present report examines the effect of different calcitonins and analogs on the in vitro phosphorylation of brain synaptic membrane proteins. The findings demonstrate that calcitonin is a potent inhibitor of several brain synaptic proteins and that salmon and eel calcitonins are considerably more potent than thyrocalcitonin in eliciting this effect. Deletion of leucine from position 16 in salmon calcitonin sequence resulted in a drastic loss of inhibitory activity, indicating the importance for a hydrophobic residue at position 16 in the intact calcitonin molecule. The mechanism of calcitonin inhibition of protein phosphorylation was likely due to the blockade of stimulation of protein kinases by calmodulin.
1985
calcitonin; brain; Synapses
01 Pubblicazione su rivista::01a Articolo in rivista
Calcitonin inhibits the phosphorylation of various proteins in rat brain synaptic membranes / Patel, J; Fabbri, A; Pert, C; Gnessi, Lucio; Fraioli, F; Mcdevitt, R.. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - STAMPA. - 130:(1985), pp. 669-676. [10.1016/0006-291X(85)90469-3]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/461093
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