Activated human T cells express class II molecules, but their capacity to present soluble antigens and stimulate T cells has been repeatedly questioned. Two lines of evidence indicate that T cells may indeed function as professional antigen-presenting cells. First, T cells that have been recently activated can efficiently capture, process and present tetanus toroid to class II-restricted T cell clones. This capacity correlates with the rate of class II synthesis. Second, activated T cell clones express high levels of B7, are powerful stimulators in mixed lymphocyte reactions, and their stumulatory capacity is inhibited by soluble CTTLA4 or anti-B7 antibody. Furthermore, expression of B7 can be detected in vivo on T cells from biopsies of patients with liver disease. Presentation of soluble antigen by activated T cells may play a role in the amplification of the specific response, and possibly in immunopathological states.
PROFESSIONAL PRESENTATION OF ANTIGEN BY ACTIVATED HUMAN T-CELLS / Barnaba, Vincenzo; Colin, Watts; M., De Boer; Peter, Lane; Antonio, Lanzavecchia. - In: EUROPEAN JOURNAL OF IMMUNOLOGY. - ISSN 0014-2980. - 24:1(1994), pp. 71-75. [10.1002/eji.1830240112]
PROFESSIONAL PRESENTATION OF ANTIGEN BY ACTIVATED HUMAN T-CELLS
BARNABA, Vincenzo;
1994
Abstract
Activated human T cells express class II molecules, but their capacity to present soluble antigens and stimulate T cells has been repeatedly questioned. Two lines of evidence indicate that T cells may indeed function as professional antigen-presenting cells. First, T cells that have been recently activated can efficiently capture, process and present tetanus toroid to class II-restricted T cell clones. This capacity correlates with the rate of class II synthesis. Second, activated T cell clones express high levels of B7, are powerful stimulators in mixed lymphocyte reactions, and their stumulatory capacity is inhibited by soluble CTTLA4 or anti-B7 antibody. Furthermore, expression of B7 can be detected in vivo on T cells from biopsies of patients with liver disease. Presentation of soluble antigen by activated T cells may play a role in the amplification of the specific response, and possibly in immunopathological states.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.