A general method for the synthesis of substituted α,α,α-[18F]-trifluorotoluenes is described. Reactions of RC6H4CCl3 (R = H, p-Cl, o-F, m-F, m-NO2) and RC6H4CF3 (R = H, m-NO2, p-NO2, o-F, m-F) with two different radiofluorinating agents, [H-18F + Sb2O3] and [H-18F + SbF3], give the corresponding α,α,α-[18F]-trifluoro derivs. in 0-75% radiochem. yield. The radioactive products yields depended upon the nature of the R substituent and the reaction conditions. A discussion on the possible reaction mechanisms involved is reported.
F-18 TO-HALOGEN EXCHANGE-REACTION ON ALPHA,ALPHA,ALPHA-TRIHALOTOLUENES - A USEFUL ROUTE TO NO-CARRIER-ADDED (NCA) F-18 LABELED SUBSTITUTED ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENES / Angelini, Giancarlo; Speranza, Maurizio; A. P., Wolf; C. Y., Shiue. - In: RADIOCHIMICA ACTA. - ISSN 0033-8230. - STAMPA. - 50:(1990), pp. 63-69.
F-18 TO-HALOGEN EXCHANGE-REACTION ON ALPHA,ALPHA,ALPHA-TRIHALOTOLUENES - A USEFUL ROUTE TO NO-CARRIER-ADDED (NCA) F-18 LABELED SUBSTITUTED ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENES
ANGELINI, Giancarlo;SPERANZA, Maurizio;
1990
Abstract
A general method for the synthesis of substituted α,α,α-[18F]-trifluorotoluenes is described. Reactions of RC6H4CCl3 (R = H, p-Cl, o-F, m-F, m-NO2) and RC6H4CF3 (R = H, m-NO2, p-NO2, o-F, m-F) with two different radiofluorinating agents, [H-18F + Sb2O3] and [H-18F + SbF3], give the corresponding α,α,α-[18F]-trifluoro derivs. in 0-75% radiochem. yield. The radioactive products yields depended upon the nature of the R substituent and the reaction conditions. A discussion on the possible reaction mechanisms involved is reported.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
