Thirteen normal children, seven males and six females, during early puberty (I-II according to Tanner), have been studied. Each subject was injected at weekly intervals and in random order with 100 μg of LHRH, 0.2 mg/kg of naloxone and 0.9% of saline in single bolus. The gonadotrophin response was evaluated. The administration of naloxone failed to elevate LH levels in any of the subjects studied, even in those who showed a clear gonadotrophin response to LHRH. Unlike the response noted in adults, endogenous opiates do not appear to exert a tonic inhibitory influence on LH secretion during early puberty.
Lack of endogenous opioid inhibitory tone on LH secretion in early puberty / F., Fraioli; M., Cappa; A., Fabbri; Gnessi, Lucio; C., Moretti; P., Borrelli; A., Isidori. - In: CLINICAL ENDOCRINOLOGY. - ISSN 0300-0664. - STAMPA. - 20:3(1984), pp. 299-305.
Lack of endogenous opioid inhibitory tone on LH secretion in early puberty
GNESSI, Lucio;
1984
Abstract
Thirteen normal children, seven males and six females, during early puberty (I-II according to Tanner), have been studied. Each subject was injected at weekly intervals and in random order with 100 μg of LHRH, 0.2 mg/kg of naloxone and 0.9% of saline in single bolus. The gonadotrophin response was evaluated. The administration of naloxone failed to elevate LH levels in any of the subjects studied, even in those who showed a clear gonadotrophin response to LHRH. Unlike the response noted in adults, endogenous opiates do not appear to exert a tonic inhibitory influence on LH secretion during early puberty.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
