Treating aryltrimethylsilanes 4-RC6H4SiMe3 (R = H, Me, MeO, Cl, Br, Ac, AcO, Me3Si) with F and AcOF provided a general method for labeling arom. compds. with 18F. Extensive 18F incorporation into the arom. ring was invariably obsd., leading to the ipso electrophilic substitution products, together with variable yields of other electrophilic substitution products. The relative extent of the 18F substitution processes [(C-Si/C-H)subst.] depends largely upon the substituent group on the arom. ring of the substrate, the leaving moiety, and the radiofluorination procedure used.
Electrophilic Radiofluorination of Aryltrimethylsilanes As A General-route To F-18-labeled Aryl Fluorides / Speranza, Maurizio; C. Y., Shiue; A. P., Wolf; D. S., Wilbur; Angelini, Giancarlo. - In: JOURNAL OF FLUORINE CHEMISTRY. - ISSN 0022-1139. - STAMPA. - 30:(1985), pp. 97-107. [10.1016/S0022-1139(00)80525-4]
Electrophilic Radiofluorination of Aryltrimethylsilanes As A General-route To F-18-labeled Aryl Fluorides
SPERANZA, Maurizio;ANGELINI, Giancarlo
1985
Abstract
Treating aryltrimethylsilanes 4-RC6H4SiMe3 (R = H, Me, MeO, Cl, Br, Ac, AcO, Me3Si) with F and AcOF provided a general method for labeling arom. compds. with 18F. Extensive 18F incorporation into the arom. ring was invariably obsd., leading to the ipso electrophilic substitution products, together with variable yields of other electrophilic substitution products. The relative extent of the 18F substitution processes [(C-Si/C-H)subst.] depends largely upon the substituent group on the arom. ring of the substrate, the leaving moiety, and the radiofluorination procedure used.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
