The cases of two children under three years of age with primary pulmonary rhabdomyosarcoma and no associated lung malformations are reported and a review of the literature is presented. In both, complete surgical removal of the tumor was performed and histologic examination revealed embryonal subtype. Flow cytometric assessment showed a tumor-cell diploid DNA content. Postoperative radio- and chemotherapy were carried out, but in spite of treatment both girls died because of disease progression, fourteen and nine months after diagnosis. The importance of associated cystic lung malformations and DNA content in predicting clinical outcome of primary pulmonary rhabdomyosarcoma is evaluated
Primary pulmonary rhabdomyosarcoma in childhood: clinico-biologic features in two cases with review of the literature / Schiavetti, Amalia; Dominici, Carlo; Matrunola, M; Capocaccia, Paolo; Ceccamea, Alberto; Castello, Manuel Adolfo. - In: MEDICAL AND PEDIATRIC ONCOLOGY. - ISSN 0098-1532. - (1996). [10.1002/(SICI)1096-911X(199603)26:3<201::AID-MPO10>3.0.CO;2-J]
Primary pulmonary rhabdomyosarcoma in childhood: clinico-biologic features in two cases with review of the literature.
SCHIAVETTI, Amalia;DOMINICI, Carlo;CAPOCACCIA, Paolo;CECCAMEA, Alberto;CASTELLO, Manuel Adolfo
1996
Abstract
The cases of two children under three years of age with primary pulmonary rhabdomyosarcoma and no associated lung malformations are reported and a review of the literature is presented. In both, complete surgical removal of the tumor was performed and histologic examination revealed embryonal subtype. Flow cytometric assessment showed a tumor-cell diploid DNA content. Postoperative radio- and chemotherapy were carried out, but in spite of treatment both girls died because of disease progression, fourteen and nine months after diagnosis. The importance of associated cystic lung malformations and DNA content in predicting clinical outcome of primary pulmonary rhabdomyosarcoma is evaluatedI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.