Hylambatin, a novel tachykinin endecapeptide isolated from the skin of the African frog Hylambates maculatus, must be ascribed to the physalaemin subfamily. It differs structurally from all other known tachykinins mainly in having a methionine residue replacing the usual leucine residue at position 2 from the C-terminus. In parallel bioassay on a number of in-vitro and in-vivo test objects, hylambatin and physalaemin were nearly indistinguishable from each other, with few moderate quantitative differences.
Parallel bioassay of physalaemin and hylambatin on smooth muscle preparations and blood pressure / Falconieri, Giuliana; Mazzanti, Gabriela; T., Yasuhara; T., Nakajima. - In: JOURNAL OF PHARMACY AND PHARMACOLOGY. - ISSN 0022-3573. - STAMPA. - 36:4(1984), pp. 284-286. [10.1111/j.2042-7158.1984.tb04374.x]
Parallel bioassay of physalaemin and hylambatin on smooth muscle preparations and blood pressure
FALCONIERI, Giuliana;MAZZANTI, Gabriela;
1984
Abstract
Hylambatin, a novel tachykinin endecapeptide isolated from the skin of the African frog Hylambates maculatus, must be ascribed to the physalaemin subfamily. It differs structurally from all other known tachykinins mainly in having a methionine residue replacing the usual leucine residue at position 2 from the C-terminus. In parallel bioassay on a number of in-vitro and in-vivo test objects, hylambatin and physalaemin were nearly indistinguishable from each other, with few moderate quantitative differences.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.