Two infants with fibrosarcoma and rhabdomyosarcoma diagnosed prenatally and at 2 months of age, respectively, and cytomegalovirus (CMV) infection are reported. Concomitant CMV infection was revealed by positive urine culture and/or CMV DNA, and CMV-specific IgM, IgA, and complement-fixing antibodies. The patients, showing very low levels of immune T cells, died at 3 and 8 months of age, respectively. A pathogenic role for CMV in the progression of the tumors is suggested.
Cytomegalovirus infection in two infants with congenital or neonatal solid tumors / Nigro, Giovanni; Uta, Bartmann; Properzi, Enrico; Andrea, Torre; Schiavetti, Amalia; Castello, Manuel Adolfo. - In: PEDIATRIC HEMATOLOGY AND ONCOLOGY. - ISSN 0888-0018. - 10:4(1993), pp. 351-355. [10.3109/08880019309029515]
Cytomegalovirus infection in two infants with congenital or neonatal solid tumors
NIGRO, Giovanni;PROPERZI, Enrico;SCHIAVETTI, Amalia;CASTELLO, Manuel Adolfo
1993
Abstract
Two infants with fibrosarcoma and rhabdomyosarcoma diagnosed prenatally and at 2 months of age, respectively, and cytomegalovirus (CMV) infection are reported. Concomitant CMV infection was revealed by positive urine culture and/or CMV DNA, and CMV-specific IgM, IgA, and complement-fixing antibodies. The patients, showing very low levels of immune T cells, died at 3 and 8 months of age, respectively. A pathogenic role for CMV in the progression of the tumors is suggested.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
