Microdosimetric models for biological cells have assumed increasing significance in the development of nanosecond pulsed electric field technology for medical applications. In this paper, novel passive element circuits, able to take into account the dielectric dispersion of the cell, are provided. The circuital analyses are performed on a set of input pulses classified in accordance with the current literature. Accurate data in terms of transmembrane potential are obtained in both time and frequency domains for different cell models. In addition, a sensitivity study of the transfer function for the cell geometrical and dielectric parameters has been carried out. This analysis offers a new, simple, and efficient tool to characterize the nsPEFs action at the cellular level. © 2012 IEEE.
Novel Passive Element Circuits for Microdosimetry of Nanosecond Pulsed Electric Fields / C., Merla; Denzi, Agnese; Paffi, Alessandra; Casciola, Maura; D'Inzeo, Guglielmo; Apollonio, Francesca; Liberti, Micaela. - In: IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING. - ISSN 0018-9294. - ELETTRONICO. - 59:8(2012), pp. 2302-2311. [10.1109/tbme.2012.2203133]
Novel Passive Element Circuits for Microdosimetry of Nanosecond Pulsed Electric Fields
DENZI, AGNESE;PAFFI, ALESSANDRA;CASCIOLA, MAURA;D'INZEO, Guglielmo;APOLLONIO, Francesca;LIBERTI, Micaela
2012
Abstract
Microdosimetric models for biological cells have assumed increasing significance in the development of nanosecond pulsed electric field technology for medical applications. In this paper, novel passive element circuits, able to take into account the dielectric dispersion of the cell, are provided. The circuital analyses are performed on a set of input pulses classified in accordance with the current literature. Accurate data in terms of transmembrane potential are obtained in both time and frequency domains for different cell models. In addition, a sensitivity study of the transfer function for the cell geometrical and dielectric parameters has been carried out. This analysis offers a new, simple, and efficient tool to characterize the nsPEFs action at the cellular level. © 2012 IEEE.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
