Ipriflavone, an isoflavone derivative, is a new drug used in an attempt to decrease bone loss in osteoporosis. Experimental studies have shown that this compound acts by inhibiting osteoclastic bone resorption both in vivo and in vitro, but the mechanism of its inhibitory action on resorbing cells remains unclear. Using bone resorption assays, video image analysis together with measurements of intracellular free calcium in isolated osteoclasts, we show here that IP directly inhibits osteoclastic activity by the modulation of intracellular free calcium.
Ipriflavone directly inhibits osteoclastic activity / Albanese, CARLINA VENERANDA; Cudd, A.; L., Argentino; A., Zambonin Zallone; I., Macintyre. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - STAMPA. - 2:199(1994), pp. 930-936.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
Titolo: | Ipriflavone directly inhibits osteoclastic activity. | |
Autori: | ||
Data di pubblicazione: | 1994 | |
Rivista: | ||
Citazione: | Ipriflavone directly inhibits osteoclastic activity / Albanese, CARLINA VENERANDA; Cudd, A.; L., Argentino; A., Zambonin Zallone; I., Macintyre. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - STAMPA. - 2:199(1994), pp. 930-936. | |
Handle: | http://hdl.handle.net/11573/459245 | |
Appartiene alla tipologia: | 01a Articolo in rivista |