A silica-bonded chiral stationary phase, containing the N,N'-3,5-dinitrobenzoyl derivative of 1R,2R-diaminocyclohexane, was used to separate the enantiomers of some amino alcohols with beta-blocking activity after their conversion to oxazolidin-2-ones. The influence of mobile phase composition (mixtures of hexane with dichloromethane, chloroform, dioxane and isopropanol) on the enantioselectivity and efficiency of the column was evaluated. Furthermore, a tandem arrangement of the chiral column and its racemic version was used to resolve all the stereoisomers of one amino alcohol containing two stereogenic centres.
Enantiomeric Separation of Amino-alcohols on Dinitrobenzoyl-diaminocyclohexane Chiral Stationary Phases / B., Gallinella; R., Cirilli; Villani, Claudio. - In: JOURNAL OF CHROMATOGRAPHY A. - ISSN 0021-9673. - STAMPA. - 639:(1993), pp. 193-196. [10.1016/0021-9673(93)80254-6]
Enantiomeric Separation of Amino-alcohols on Dinitrobenzoyl-diaminocyclohexane Chiral Stationary Phases
VILLANI, Claudio
1993
Abstract
A silica-bonded chiral stationary phase, containing the N,N'-3,5-dinitrobenzoyl derivative of 1R,2R-diaminocyclohexane, was used to separate the enantiomers of some amino alcohols with beta-blocking activity after their conversion to oxazolidin-2-ones. The influence of mobile phase composition (mixtures of hexane with dichloromethane, chloroform, dioxane and isopropanol) on the enantioselectivity and efficiency of the column was evaluated. Furthermore, a tandem arrangement of the chiral column and its racemic version was used to resolve all the stereoisomers of one amino alcohol containing two stereogenic centres.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
