The gonadal function of 38 patients with Hodgkin's disease (HD) treated with MOPP chemotherapy (12 patients), ABVD (9 patients) and alternating MOPP/ABVD (17 patients) has been retrospectively investigated with semen analysis. Median age of patients was 25 years (range 16-41 years). Azoospermia was found in all patients from the MOPP group (100\%), in 3 of the ABVD group (33\%) and in 13 of the MOPP/ABVD group (76\%). After temporary oligospermia full recovery of spermatogenesis was observed in 67\% of patients treated with ABVD, versus 25\% of MOPP-treated patients following a prolonged period of azoospermia and oligospermia. Patients receiving MOPP/ABVD scheme had complete recovery of testicular function after oligospermia in 24\% of cases. These results confirm the higher gonadal toxicity of the MOPP regimen as compared to others such as ABVD without alkylating agents.
Risk of infertility in patients with Hodgkin's disease treated with ABVD vs MOPP vs ABVD/MOPP / Anselmo, Anna Paola; C., Cartoni; P., Bellantuono; MAURIZI ENRICI, Riccardo; N., Aboulkair; M., Ermini. - In: HAEMATOLOGICA. - ISSN 0390-6078. - STAMPA. - 75:(1990), pp. 155-158.
Risk of infertility in patients with Hodgkin's disease treated with ABVD vs MOPP vs ABVD/MOPP.
ANSELMO, Anna Paola;MAURIZI ENRICI, Riccardo;
1990
Abstract
The gonadal function of 38 patients with Hodgkin's disease (HD) treated with MOPP chemotherapy (12 patients), ABVD (9 patients) and alternating MOPP/ABVD (17 patients) has been retrospectively investigated with semen analysis. Median age of patients was 25 years (range 16-41 years). Azoospermia was found in all patients from the MOPP group (100\%), in 3 of the ABVD group (33\%) and in 13 of the MOPP/ABVD group (76\%). After temporary oligospermia full recovery of spermatogenesis was observed in 67\% of patients treated with ABVD, versus 25\% of MOPP-treated patients following a prolonged period of azoospermia and oligospermia. Patients receiving MOPP/ABVD scheme had complete recovery of testicular function after oligospermia in 24\% of cases. These results confirm the higher gonadal toxicity of the MOPP regimen as compared to others such as ABVD without alkylating agents.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
