Mammalian artificial chromosomes might prove to be useful vectors for somatic gene therapy. The functional elements of such an artificial chromosome are telomeres, a centromere and a replication origin. Recent progress in the characterization of these functional elements of the eukaryotic chromosome will be described. Attempts to construct artificial chromosomes for mammalian cells and their use for somatic gene therapy are discussed.
MAMMALIAN ARTIFICIAL CHROMOSOMES-VECTORS FOR SOMATIC GENE THERAPY / Ascenzioni, Fiorentina; Donini, Pierluigi; Lipps, H. J.. - In: CANCER LETTERS. - ISSN 0304-3835. - 118:2(1997), pp. 135-142. [10.1016/S0304-3835(97)00323-6]
MAMMALIAN ARTIFICIAL CHROMOSOMES-VECTORS FOR SOMATIC GENE THERAPY.
ASCENZIONI, Fiorentina;DONINI, Pierluigi;
1997
Abstract
Mammalian artificial chromosomes might prove to be useful vectors for somatic gene therapy. The functional elements of such an artificial chromosome are telomeres, a centromere and a replication origin. Recent progress in the characterization of these functional elements of the eukaryotic chromosome will be described. Attempts to construct artificial chromosomes for mammalian cells and their use for somatic gene therapy are discussed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
