A set of polyphenol compounds was synthesized and assayed for their ability in inhibiting influenza A virus replication. A sub-set of them showed low toxicity. The best compounds within this sub-set were 4 and 6g, which inhibited the viral replication in a dose-dependent manner. The antiviral activity of these molecules was demonstrated to be caused by their interference with intracellular pathways exploited for viral replication: (1) MAP kinases controlling nuclear-cytoplasmic traffic of viral ribonucleoprotein complex; (2) redox-sensitive pathways, involved in maturation of viral hemagglutinin protein. (C) 2012 Elsevier Ltd. All rights reserved.
Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action / Fioravanti, Rossella; Celestino, Ignacio; Costi, Roberta; CUZZUCOLI CRUCITTI, Giuliana; Pescatori, Luca; Mattiello, Leonardo; Ettore, Novellino; Paola, Checconi; Palamara, ANNA TERESA; Nencioni, Lucia; DI SANTO, Roberto. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - STAMPA. - 20:16(2012), pp. 5046-5052. [10.1016/j.bmc.2012.05.062]
Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action
FIORAVANTI, Rossella;CELESTINO, IGNACIO;COSTI, Roberta;CUZZUCOLI CRUCITTI, GIULIANA;PESCATORI, LUCA;MATTIELLO, Leonardo;PALAMARA, ANNA TERESA;NENCIONI, Lucia;DI SANTO, Roberto
2012
Abstract
A set of polyphenol compounds was synthesized and assayed for their ability in inhibiting influenza A virus replication. A sub-set of them showed low toxicity. The best compounds within this sub-set were 4 and 6g, which inhibited the viral replication in a dose-dependent manner. The antiviral activity of these molecules was demonstrated to be caused by their interference with intracellular pathways exploited for viral replication: (1) MAP kinases controlling nuclear-cytoplasmic traffic of viral ribonucleoprotein complex; (2) redox-sensitive pathways, involved in maturation of viral hemagglutinin protein. (C) 2012 Elsevier Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
