Increased cytokine expression contributes to the pathogenesis of cancer anorexiacachexia syndrome. Carnitine may reduce inflammation in chronic diseases. We tested the effects of L-propionylcarnitine (PC group) or saline (C group) on food intake (FI), body composition, and inflammatory status of MCA-sarcoma-bearing rats. On tumor appearance, rats were randomly assigned to daily i.p. injection of L-propionylcarnitine (250 mg/kgBW/d; n = 8) or saline (equal volume; n = 8). FI and fat-free mass wasting improved in PC rats only (p < .01 vs. controls). Cytokines' levels decreased in PC rats vs. controls (p < .02). Results suggest that carnitine may ameliorate cancer anorexiacachexia, via reduction of the inflammatory status. © 2011 Informa Healthcare USA, Inc.
Carnitine administration reduces cytokine levels, improves food intake, and ameliorates body composition in tumor-bearing rats / Laviano, Alessandro; Molfino, Alessio; Marilia, Seelaender; Teresa, Frascaria; Giuseppe, Bertini; Cesarina, Ramaccini; Maria Rosa, Bollea; Gennaro, Citro; ROSSI FANELLI, Filippo. - In: CANCER INVESTIGATION. - ISSN 0735-7907. - 29:10(2011), pp. 696-700. [10.3109/07357907.2011.626476]
Carnitine administration reduces cytokine levels, improves food intake, and ameliorates body composition in tumor-bearing rats.
LAVIANO, Alessandro;MOLFINO, ALESSIO;ROSSI FANELLI, Filippo
2011
Abstract
Increased cytokine expression contributes to the pathogenesis of cancer anorexiacachexia syndrome. Carnitine may reduce inflammation in chronic diseases. We tested the effects of L-propionylcarnitine (PC group) or saline (C group) on food intake (FI), body composition, and inflammatory status of MCA-sarcoma-bearing rats. On tumor appearance, rats were randomly assigned to daily i.p. injection of L-propionylcarnitine (250 mg/kgBW/d; n = 8) or saline (equal volume; n = 8). FI and fat-free mass wasting improved in PC rats only (p < .01 vs. controls). Cytokines' levels decreased in PC rats vs. controls (p < .02). Results suggest that carnitine may ameliorate cancer anorexiacachexia, via reduction of the inflammatory status. © 2011 Informa Healthcare USA, Inc.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
