Acetylcholine receptor (AChR) was found to be present on the cell surface of the human rhabdomyoblast (RD) cell line. Two classes of ACh-activated channels have been observed, one with a large conductance and long duration and the other with smaller conductance and short duration, similar to those of human myotubes. RD membrane exhibited a specific binding to the α-bungarotoxin indicating the presence of nicotinic AChRs. These results support the hypothesis that rhabdomyosarcomas derive from myogenic precursors.
SINGLE ACETYLCHOLINE-ACTIVATED CHANNELS IN CULTURED RHABDOMYOBLASTS / Grassi, Francesca; Bouche', Marina; Aguanno, Salvatore; Molinaro, Mario; Eusebi, Fabrizio. - In: EXPERIMENTAL CELL RESEARCH. - ISSN 0014-4827. - 171:2(1987), pp. 498-502. [10.1016/0014-4827(87)90181-9]
SINGLE ACETYLCHOLINE-ACTIVATED CHANNELS IN CULTURED RHABDOMYOBLASTS
GRASSI, Francesca;BOUCHE', Marina;AGUANNO, Salvatore;MOLINARO, Mario;EUSEBI, Fabrizio
1987
Abstract
Acetylcholine receptor (AChR) was found to be present on the cell surface of the human rhabdomyoblast (RD) cell line. Two classes of ACh-activated channels have been observed, one with a large conductance and long duration and the other with smaller conductance and short duration, similar to those of human myotubes. RD membrane exhibited a specific binding to the α-bungarotoxin indicating the presence of nicotinic AChRs. These results support the hypothesis that rhabdomyosarcomas derive from myogenic precursors.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
