The distribution of aspirin and salicylate 30 min after the intravenous administration of different doses of aspirin has been investigated in the rabbit eye. HPLC enabled a rapid and sensitive determination of both substances. A considerable dose-dependent penetration into all ocular tissues was observed with both aspirin and salicylate. Aspirin concentrations were higher than in plasma in all ocular tissues with the exception of the lens. These results show that an unhydrolysed drug may have a direct local effect by acetylating lens protein or other ocular constituents.
OCULAR DISTRIBUTION OF ASPIRIN AND SALICYLATE FOLLOWING SYSTEMATIC ADMINISTRATION OF ASPIRIN TO RABBITS / Valeri, Pacifico; Romanelli, Luca; L. D., Paolis; B., Martinelli. - In: JOURNAL OF PHARMACY AND PHARMACOLOGY. - ISSN 0022-3573. - STAMPA. - 40:11(1988), pp. 823-824. [10.1111/j.2042-7158.1988.tb05185.x]
OCULAR DISTRIBUTION OF ASPIRIN AND SALICYLATE FOLLOWING SYSTEMATIC ADMINISTRATION OF ASPIRIN TO RABBITS
VALERI, Pacifico;ROMANELLI, LUCA;
1988
Abstract
The distribution of aspirin and salicylate 30 min after the intravenous administration of different doses of aspirin has been investigated in the rabbit eye. HPLC enabled a rapid and sensitive determination of both substances. A considerable dose-dependent penetration into all ocular tissues was observed with both aspirin and salicylate. Aspirin concentrations were higher than in plasma in all ocular tissues with the exception of the lens. These results show that an unhydrolysed drug may have a direct local effect by acetylating lens protein or other ocular constituents.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
