Time-courses of both 'total' (unchanged plus metabolized) and unmetabolized acetaminophen were investigated in plasma and ocular tissues of rabbit after intravenous administration. The drug freely diffuses across the haemato-ocular barriers, reaching eye levels equal to those in the plasma; ocular concentrations are higher than those of all other investigated drugs. The time-course in aqueous is superimposable to that observed in the plasma; in other ocular tissues it is much slower. There is evidence of an ocular metabolism or a concentration into the eye of minor metabolites formed elsewhere.
OCULAR DISPOSITION OF ACETAMINOPHEN AND ITS METABOLITES FOLLOWING INTRAVENOUS ADMINISTRATION IN RABBITS / Romanelli, Luca; Valeri, Pacifico; Luigi Antonio, Morrone; Giuseppe, Pimpinella. - In: JOURNAL OF OCULAR PHARMACOLOGY. - ISSN 8756-3320. - STAMPA. - 7:4(1991), pp. 339-350. [10.1089/jop.1991.7.339]
OCULAR DISPOSITION OF ACETAMINOPHEN AND ITS METABOLITES FOLLOWING INTRAVENOUS ADMINISTRATION IN RABBITS
ROMANELLI, LUCA;VALERI, Pacifico;
1991
Abstract
Time-courses of both 'total' (unchanged plus metabolized) and unmetabolized acetaminophen were investigated in plasma and ocular tissues of rabbit after intravenous administration. The drug freely diffuses across the haemato-ocular barriers, reaching eye levels equal to those in the plasma; ocular concentrations are higher than those of all other investigated drugs. The time-course in aqueous is superimposable to that observed in the plasma; in other ocular tissues it is much slower. There is evidence of an ocular metabolism or a concentration into the eye of minor metabolites formed elsewhere.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
