The acute effects of non steroidal anti-inflammatory drugs (NSAIDs) were studied on guinea-pig ileum isolated preparation. Two cyclo-oxygenase inhibitors, aspirin and indometacin, and two NSAID devoid of this effect, salicylic acid and benzydamine, were injected into the bath 1 min before PGE1 or CCK-8. All drugs tested elicited a dose-related inhibition of the neuronally evoked contractile responses to submaximal dose of PGE1 and CCK-8. These drugs depressed also the opioid system(s) activated by PGE1 or CCK-8. These results indicate that the inhibition of neuronally evoked response is a common mechanism of NSAIDs. This mechanism may have an important role on analgesic and anti-inflammatory action of these drugs.
Aspirin-like drugs inhibit neuronally evoked responses in isolated guinea-pig ileum / Valeri, Pacifico; L. A., Morrone; Romanelli, Luca; M. C., Amico. - In: ANNALI DELL'ISTITUTO SUPERIORE DI SANITÀ. - ISSN 0021-2571. - STAMPA. - 29:3(1993), pp. 379-385.
Aspirin-like drugs inhibit neuronally evoked responses in isolated guinea-pig ileum
VALERI, Pacifico;ROMANELLI, LUCA;
1993
Abstract
The acute effects of non steroidal anti-inflammatory drugs (NSAIDs) were studied on guinea-pig ileum isolated preparation. Two cyclo-oxygenase inhibitors, aspirin and indometacin, and two NSAID devoid of this effect, salicylic acid and benzydamine, were injected into the bath 1 min before PGE1 or CCK-8. All drugs tested elicited a dose-related inhibition of the neuronally evoked contractile responses to submaximal dose of PGE1 and CCK-8. These drugs depressed also the opioid system(s) activated by PGE1 or CCK-8. These results indicate that the inhibition of neuronally evoked response is a common mechanism of NSAIDs. This mechanism may have an important role on analgesic and anti-inflammatory action of these drugs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
