In this study we asked whether subthalamic nucleus deep brain stimulation (STN-DBS) alone, or in combination with L-dopa, modifies voluntary, spontaneous and reflex blinking in patients with Parkinson's disease (PD). Sixteen PD patients who underwent STN-DBS were studied in four experimental conditions: without STN-DBS and without L-dopa, STN-DBS alone, L-dopa alone and STN-DBS plus L-dopa. The results were compared with those obtained in 15 healthy controls. Voluntary blinking was assessed by asking participants to blink as fast as possible; spontaneous blinking was recorded during two 60 s rest periods; reflex blinking was evoked by electrical stimulation of the supraorbital nerve. Blinking were recorded and analysed with the SMART motion system. STN-DBS increased the peak velocity and amplitude for both the closing and opening voluntary blink phases, but prolonged the inter-phase pause duration. L-dopa had no effects on voluntary blinking but reversed the increased inter-phase pause duration seen during STN-DBS. Spontaneous blink rate increased after either STN-DBS or L-dopa. Reflex blinking kinematics were not modified by STN-DBS or L-dopa. The STN-DBS effects on voluntary blinking kinematics and spontaneous blinking rate may occur as results of changes of cortico-basal ganglia activity. The prolonged pause duration of voluntary blinking indicates that STN-DBS has detrimental effects on the cranial region. These results also shed light on the pathophysiology of eyelids opening apraxia following STN-DBS. (C) 2012 Elsevier Inc. All rights reserved.

Effects of subthalamic nucleus deep brain stimulation and l-dopa on blinking in Parkinson's disease / Bologna, Matteo; Alfonso, Fasano; Nicola, Modugno; Fabbrini, Giovanni; Berardelli, Alfredo. - In: EXPERIMENTAL NEUROLOGY. - ISSN 0014-4886. - 235:1(2012), pp. 265-272. [10.1016/j.expneurol.2012.02.004]

Effects of subthalamic nucleus deep brain stimulation and l-dopa on blinking in Parkinson's disease

BOLOGNA, Matteo;FABBRINI, Giovanni;BERARDELLI, Alfredo
2012

Abstract

In this study we asked whether subthalamic nucleus deep brain stimulation (STN-DBS) alone, or in combination with L-dopa, modifies voluntary, spontaneous and reflex blinking in patients with Parkinson's disease (PD). Sixteen PD patients who underwent STN-DBS were studied in four experimental conditions: without STN-DBS and without L-dopa, STN-DBS alone, L-dopa alone and STN-DBS plus L-dopa. The results were compared with those obtained in 15 healthy controls. Voluntary blinking was assessed by asking participants to blink as fast as possible; spontaneous blinking was recorded during two 60 s rest periods; reflex blinking was evoked by electrical stimulation of the supraorbital nerve. Blinking were recorded and analysed with the SMART motion system. STN-DBS increased the peak velocity and amplitude for both the closing and opening voluntary blink phases, but prolonged the inter-phase pause duration. L-dopa had no effects on voluntary blinking but reversed the increased inter-phase pause duration seen during STN-DBS. Spontaneous blink rate increased after either STN-DBS or L-dopa. Reflex blinking kinematics were not modified by STN-DBS or L-dopa. The STN-DBS effects on voluntary blinking kinematics and spontaneous blinking rate may occur as results of changes of cortico-basal ganglia activity. The prolonged pause duration of voluntary blinking indicates that STN-DBS has detrimental effects on the cranial region. These results also shed light on the pathophysiology of eyelids opening apraxia following STN-DBS. (C) 2012 Elsevier Inc. All rights reserved.
2012
blinking; deep brain stimulation; motor control; parkinson's disease; subthalamic nucleus
01 Pubblicazione su rivista::01a Articolo in rivista
Effects of subthalamic nucleus deep brain stimulation and l-dopa on blinking in Parkinson's disease / Bologna, Matteo; Alfonso, Fasano; Nicola, Modugno; Fabbrini, Giovanni; Berardelli, Alfredo. - In: EXPERIMENTAL NEUROLOGY. - ISSN 0014-4886. - 235:1(2012), pp. 265-272. [10.1016/j.expneurol.2012.02.004]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/455797
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