We designed a new paired associative stimulation (PAS) protocol that combines experimental pain evoked by laser stimuli and transcranial magnetic stimulation (TMS) (Laser-PAS) to primary motor cortex (M1). We tested in healthy subjects whether Laser-PAS elicits cortical plasticity as reflected by long-term changes in motor-evoked potentials (MEPs) (after-effects). In separate experiments, we examined numerous variables including changes induced by varying the interstimulus intervals (ISIs) and Laser-PAS-induced changes in target and non-target muscle MEPs. We measured MEPs after repetitive laser or TMS (rTMS) pulses, and compared magnetic- and electric (TES)-induced MEPs. We tested MEPs after applying Laser-PAS with laser pulses ipsilaterally to M1. Finally, we studied subjects receiving an N-methyl-d-aspartate (NMDA) receptor antagonist (memantine) or placebo (-lipoic acid). During Laser-PAS at the 50 ms ISI MEPs decreased, thereafter they increased for 60 min; other ISIs induced no after-effects. The after-effects remained restricted to the target muscle. Repetitive laser pulses and rTMS induced no after-effects. After Laser-PAS, TMS-induced MEPs increased, whereas TES-induced MEPs did not. Laser-PAS with laser pulses ipsilaterally to M1 left MEPs unchanged. Memantine, but not -lipoic acid, abolished the after-effects. In conclusion, Laser-PAS elicits NMDA-dependent cortical plasticity and provides new insights into human pain-motor integration.

Heat-Evoked Experimental Pain Induces Long-Term Potentiation-Like Plasticity in Human Primary Motor Cortex / Suppa, Antonio; Biasiotta, Antonella; Belvisi, Daniele; Marsili, Luca; LA CESA, Silvia; Truini, Andrea; Cruccu, Giorgio; Berardelli, Alfredo. - In: CEREBRAL CORTEX. - ISSN 1047-3211. - 23:8(2013), pp. 1942-1951. [10.1093/cercor/bhs182]

Heat-Evoked Experimental Pain Induces Long-Term Potentiation-Like Plasticity in Human Primary Motor Cortex

SUPPA, ANTONIO;BIASIOTTA, ANTONELLA;BELVISI, DANIELE;MARSILI, LUCA;LA CESA, SILVIA;TRUINI, ANDREA;CRUCCU, Giorgio;BERARDELLI, Alfredo
2013

Abstract

We designed a new paired associative stimulation (PAS) protocol that combines experimental pain evoked by laser stimuli and transcranial magnetic stimulation (TMS) (Laser-PAS) to primary motor cortex (M1). We tested in healthy subjects whether Laser-PAS elicits cortical plasticity as reflected by long-term changes in motor-evoked potentials (MEPs) (after-effects). In separate experiments, we examined numerous variables including changes induced by varying the interstimulus intervals (ISIs) and Laser-PAS-induced changes in target and non-target muscle MEPs. We measured MEPs after repetitive laser or TMS (rTMS) pulses, and compared magnetic- and electric (TES)-induced MEPs. We tested MEPs after applying Laser-PAS with laser pulses ipsilaterally to M1. Finally, we studied subjects receiving an N-methyl-d-aspartate (NMDA) receptor antagonist (memantine) or placebo (-lipoic acid). During Laser-PAS at the 50 ms ISI MEPs decreased, thereafter they increased for 60 min; other ISIs induced no after-effects. The after-effects remained restricted to the target muscle. Repetitive laser pulses and rTMS induced no after-effects. After Laser-PAS, TMS-induced MEPs increased, whereas TES-induced MEPs did not. Laser-PAS with laser pulses ipsilaterally to M1 left MEPs unchanged. Memantine, but not -lipoic acid, abolished the after-effects. In conclusion, Laser-PAS elicits NMDA-dependent cortical plasticity and provides new insights into human pain-motor integration.
2013
tms; spike timing-dependent plasticity; primary motor cortex; laser-evoked potentials; pain-motor integration
01 Pubblicazione su rivista::01a Articolo in rivista
Heat-Evoked Experimental Pain Induces Long-Term Potentiation-Like Plasticity in Human Primary Motor Cortex / Suppa, Antonio; Biasiotta, Antonella; Belvisi, Daniele; Marsili, Luca; LA CESA, Silvia; Truini, Andrea; Cruccu, Giorgio; Berardelli, Alfredo. - In: CEREBRAL CORTEX. - ISSN 1047-3211. - 23:8(2013), pp. 1942-1951. [10.1093/cercor/bhs182]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/455780
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