Bronchiolitis is a lower respiratory tract viral infection which may result in severe bronchial obstruction and respiratory failure despite treatment with beta-adrenergic agonists and glucocorticoids. Here we describe two otherwise healthy infants with severe bronchiolitis whose clinical course was complicated by marked bronchial obstruction and respiratory acidosis refractory to conventional medications (beta-stimulants, anticholinergics and corticosteroids) and non-invasive positive pressure ventilation. Sevoflurane inhalation allowed both infants to attain a sustained, clinical improvement in ventilation and one patient to avoid mechanical ventilation. We suggest that sevoflurane inhalation may be a therapeutic option in the treatment of young infants with severe bronchiolitis who respond poorly to conventional therapy.

SEVOFLURANE INHALATION FOR SEVERE BRONCHIAL OBSTRUCTION IN INFANTS WITH BRONCHIOLITIS / Papoff, Paola; Caresta, E.; Gazzanelli, S.; Pinto, R.; Cerasaro, C.; Moretti, Corrado; Midulla, Fabio. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - 25:2(2012), pp. 493-497.

SEVOFLURANE INHALATION FOR SEVERE BRONCHIAL OBSTRUCTION IN INFANTS WITH BRONCHIOLITIS

PAPOFF, PAOLA;MORETTI, Corrado;MIDULLA, Fabio
2012

Abstract

Bronchiolitis is a lower respiratory tract viral infection which may result in severe bronchial obstruction and respiratory failure despite treatment with beta-adrenergic agonists and glucocorticoids. Here we describe two otherwise healthy infants with severe bronchiolitis whose clinical course was complicated by marked bronchial obstruction and respiratory acidosis refractory to conventional medications (beta-stimulants, anticholinergics and corticosteroids) and non-invasive positive pressure ventilation. Sevoflurane inhalation allowed both infants to attain a sustained, clinical improvement in ventilation and one patient to avoid mechanical ventilation. We suggest that sevoflurane inhalation may be a therapeutic option in the treatment of young infants with severe bronchiolitis who respond poorly to conventional therapy.
2012
bronchiolitis; infants; mechanical ventilation; non invasive ventilation; pediatric intensive care; sevoflurane
01 Pubblicazione su rivista::01a Articolo in rivista
SEVOFLURANE INHALATION FOR SEVERE BRONCHIAL OBSTRUCTION IN INFANTS WITH BRONCHIOLITIS / Papoff, Paola; Caresta, E.; Gazzanelli, S.; Pinto, R.; Cerasaro, C.; Moretti, Corrado; Midulla, Fabio. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - 25:2(2012), pp. 493-497.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/455609
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