A Caucasian, male, young adult with recurrent agitated depression and suicidal ideation received lithium and oral olanzapine. His white blood cell count was normal at that time. Due to unsatisfactory response, he received 4 mg/day risperidone. While symptoms improved, leukopenia emerged, specifically directed towards neutrophils. Upon risperidone discontinuation, white blood cell count returned to reference values within 1 week. As symptom control was satisfactory, we attempted no risperidone rechallenge. Accurate blood testing must accompany atypical antipsychotic drug administration since blood dyscrasias are always possible with these drugs. (C) 2013 Elsevier Inc. All rights reserved.
Risperidone-induced leukopenia: a case report and brief review of literature / Giovanni, Manfredi; Solfanelli, Andrea; Giorgia, Dimitri; Cuomo, Ilaria; Sani, Gabriele; Kotzalidis, Giorgio; Girardi, Paolo. - In: GENERAL HOSPITAL PSYCHIATRY. - ISSN 0163-8343. - 35:1(2013), pp. 102.e3-102.e6. [10.1016/j.genhosppsych.2012.03.009]
Risperidone-induced leukopenia: a case report and brief review of literature
SOLFANELLI, ANDREA;CUOMO, ILARIA;SANI, Gabriele;KOTZALIDIS, GIORGIO;GIRARDI, Paolo
2013
Abstract
A Caucasian, male, young adult with recurrent agitated depression and suicidal ideation received lithium and oral olanzapine. His white blood cell count was normal at that time. Due to unsatisfactory response, he received 4 mg/day risperidone. While symptoms improved, leukopenia emerged, specifically directed towards neutrophils. Upon risperidone discontinuation, white blood cell count returned to reference values within 1 week. As symptom control was satisfactory, we attempted no risperidone rechallenge. Accurate blood testing must accompany atypical antipsychotic drug administration since blood dyscrasias are always possible with these drugs. (C) 2013 Elsevier Inc. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
