Lack of oxidative damage in serum polyunsaturated fatty acids before and after dialysis in chronic uremic patients

Taccone Gallucci, M; Lubrano, Riccardo; Belli, A; Citti, G; Morosetti, M; Meloni, C; Elli, M; Mazzarella, V; Tozzo, C; Meschini, L; Giardini, O; Casciani, Cu

We described previously that in the erythrocytes and mononuclear blood cells from uremic patients on chronic hemodialysis, the membrane concentrations of malonyldialdehyde (MDA), resulting from peroxidation of polyunsaturated fatty acids (PUFA) in the membrane itself increased, and the concentrations of vitamin E (VIT E), the major antioxidizing agent, were lower. In the present study we analysed whether similar oxidative damage is seen in the serum from hemodialysis patients and whether the serum fatty acid pattern is affected. No evidence was found of oxidative damage in the serum during hemodialysis, serum concentrations of MDA and VIT E remaining constant before and after dialysis. No change was observed in serum pattern of PUFA, particularly linoleic acid. We therefore assume that the oxidative damage described in uremic patients is mainly intracellular.

Lack of oxidative damage in serum polyunsaturated fatty acids before and after dialysis in chronic uremic patients / Taccone Gallucci, M; Lubrano, Riccardo; Belli, A; Citti, G; Morosetti, M; Meloni, C; Elli, M; Mazzarella, V; Tozzo, C; Meschini, L; Giardini, O; Cu, Casciani. - In: INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS. - ISSN 0391-3988. - STAMPA. - 12(1989), pp. 515-518.

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Titolo:	Lack of oxidative damage in serum polyunsaturated fatty acids before and after dialysis in chronic uremic patients
Autori:	Taccone Gallucci M LUBRANO, Riccardo Belli A Citti G Morosetti M Meloni C Elli M Mazzarella V Tozzo C Meschini L Giardini O CU Casciani mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1989
Rivista:	INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
Citazione:	Lack of oxidative damage in serum polyunsaturated fatty acids before and after dialysis in chronic uremic patients / Taccone Gallucci, M; Lubrano, Riccardo; Belli, A; Citti, G; Morosetti, M; Meloni, C; Elli, M; Mazzarella, V; Tozzo, C; Meschini, L; Giardini, O; Cu, Casciani. - In: INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS. - ISSN 0391-3988. - STAMPA. - 12(1989), pp. 515-518.
Handle:	http://hdl.handle.net/11573/454411
Appartiene alla tipologia:	01a Articolo in rivista

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