To investigate calcitonin secretion in primary hyperparathyroidism, basal and stimulated (3 mg Ca++/kg body weight/10 min) immunoreactive calcitonin plasma levels were studied before parathyroidectomy. Plasma calcitonin levels were raised in 50% of patients regardless of sex, but a significant correlation between basal plasma calcium and calcitonin was found only in males. A reduced calcitonin response to calcium infusion was observed in all patients. Parathyroidectomy invariably induced a normalization of calcitonin basal levels. Our findings confirm the existence of a decreased parafollicular cell reserve probably as a consequence of the persistent hypercalcemic state in hyperparathyroid patients and suggest that it is more frequent in females.
BASAL AND STIMULATED CALCITONIN SECRETION IN PRIMARY HYPERPARATHYROIDISM BEFORE AND AFTER PARATHYROIDECTOMY / S., Tabolli; C., Valtorta; F., Bigi; Minisola, Salvatore; G. F., Mazzuoli. - In: HORMONE RESEARCH. - ISSN 0301-0163. - ELETTRONICO. - 23:3(1986), pp. 142-146. [10.1159/000180309]
BASAL AND STIMULATED CALCITONIN SECRETION IN PRIMARY HYPERPARATHYROIDISM BEFORE AND AFTER PARATHYROIDECTOMY
MINISOLA, Salvatore;
1986
Abstract
To investigate calcitonin secretion in primary hyperparathyroidism, basal and stimulated (3 mg Ca++/kg body weight/10 min) immunoreactive calcitonin plasma levels were studied before parathyroidectomy. Plasma calcitonin levels were raised in 50% of patients regardless of sex, but a significant correlation between basal plasma calcium and calcitonin was found only in males. A reduced calcitonin response to calcium infusion was observed in all patients. Parathyroidectomy invariably induced a normalization of calcitonin basal levels. Our findings confirm the existence of a decreased parafollicular cell reserve probably as a consequence of the persistent hypercalcemic state in hyperparathyroid patients and suggest that it is more frequent in females.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.