The pathogenetic factors of postmenopausal and senile osteoporosis are reviewed. Both postmenopausal and senile osteoporosis occur as a result of a defective regulation of bone remodelling which leads to a negative uncoupling between bone resorption and bone formation. Systemic and local factors contribute to the development of the phenomenon. While studies of the systemic factors involved in age-related bone loss are well advanced, although still incomplete, the study of the local factors responsible at a tissue level for the negative skeletal balance has barely begun. © 1989 Springer-Verlag.
Pathogenethic aspects of involutional osteoporosis / G. F., Mazzuoli; D'Erasmo, Emilio; Minisola, Salvatore; S., Tabolli; F., Bigi; G., Bianchi. - In: CLINICAL RHEUMATOLOGY. - ISSN 0770-3198. - ELETTRONICO. - 8:2 Supplement(1989), pp. 22-29. [10.1007/bf02207229]
Pathogenethic aspects of involutional osteoporosis
D'ERASMO, Emilio;MINISOLA, Salvatore;
1989
Abstract
The pathogenetic factors of postmenopausal and senile osteoporosis are reviewed. Both postmenopausal and senile osteoporosis occur as a result of a defective regulation of bone remodelling which leads to a negative uncoupling between bone resorption and bone formation. Systemic and local factors contribute to the development of the phenomenon. While studies of the systemic factors involved in age-related bone loss are well advanced, although still incomplete, the study of the local factors responsible at a tissue level for the negative skeletal balance has barely begun. © 1989 Springer-Verlag.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
