This study was performed in order to evaluate the clinical usefulness of the measurement of total serum alkaline phosphatase activity (AP), serum osteocalcin (BGP) and urinary hydroxyproline (OHPr) in assessing bone remodelling in primary hyperparathyroidism. Thirty-two patients with primary hyperparathyroidism were included in the study. No statistically significant differences were observed between the mean values of Z-scores obtained for each marker. Furthermore, an inverse correlation was found between percentage of bone mineral content at the distal radius and both BPG (r = -0.57; p <0.05) and AP (r = -0.49; p <0.05). The results obtained demonstrate that, contrary to other metabolic bone diseases (e.g. Paget's disease of bone), all three markers examined may be used in clinical practice to evaluate the entity of skeletal turnover in primary hyperparathyroidism.
CLINICAL-VALUE OF THE MEASUREMENT OF BONE REMODELING MARKERS IN PRIMARY HYPERPARATHYROIDISM / Minisola, Salvatore; L., Scarnecchia; V., Carnevale; F., Bigi; E., Romagnoli; M. T., Pacitti; R., Rosso; G. F., Mazzuoli. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - ELETTRONICO. - 12:8(1989), pp. 537-542.
CLINICAL-VALUE OF THE MEASUREMENT OF BONE REMODELING MARKERS IN PRIMARY HYPERPARATHYROIDISM
MINISOLA, Salvatore;
1989
Abstract
This study was performed in order to evaluate the clinical usefulness of the measurement of total serum alkaline phosphatase activity (AP), serum osteocalcin (BGP) and urinary hydroxyproline (OHPr) in assessing bone remodelling in primary hyperparathyroidism. Thirty-two patients with primary hyperparathyroidism were included in the study. No statistically significant differences were observed between the mean values of Z-scores obtained for each marker. Furthermore, an inverse correlation was found between percentage of bone mineral content at the distal radius and both BPG (r = -0.57; p <0.05) and AP (r = -0.49; p <0.05). The results obtained demonstrate that, contrary to other metabolic bone diseases (e.g. Paget's disease of bone), all three markers examined may be used in clinical practice to evaluate the entity of skeletal turnover in primary hyperparathyroidism.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.