The effects of oophorectomy on the biological indices of bone remodelling and the time-course of their changes are described. In the first few months following surgical menopause the measurement of the markers of bone remodelling indicates that the increase in osteogenesis is delayed compared with that of bone resorption; this prevalence of destruction over new bone deposition justifies the deficiency of skeletal balance, shortly after acute oestrogen deficiency. The changes in bone remodelling are accompanied by an increase in serum calcium while serum immunoreactive parathyroid hormone levels remain unchanged or even decrease, suggesting a shift to right of the parathyroid gland set-point. The reasons for the negative skeletal balance after oophorectomy might be sought therefore at bone tissue level, even if changes in responsiveness and/or of the parathyroid gland set-point could also be contributory.
THE EFFECTS OF OOPHORECTOMY ON SKELETAL METABOLISM / G., Mazzuoli; Minisola, Salvatore; G., Bianchi; M. T., Pacitti; R., Rosso; E., Romagnoli; V., Carnevale; L., Scarnecchia; F. S., Celi; V., Ortore. - In: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. - ISSN 0960-0760. - ELETTRONICO. - 37:3(1990), pp. 457-459. ( 14TH MEETING OF THE INTERNATIONAL STUDY GROUP FOR STEROID HORMONES ROME, ITALY NOV 30-DEC 02, 1989) [10.1016/0960-0760(90)90498-a].
THE EFFECTS OF OOPHORECTOMY ON SKELETAL METABOLISM
MINISOLA, Salvatore;
1990
Abstract
The effects of oophorectomy on the biological indices of bone remodelling and the time-course of their changes are described. In the first few months following surgical menopause the measurement of the markers of bone remodelling indicates that the increase in osteogenesis is delayed compared with that of bone resorption; this prevalence of destruction over new bone deposition justifies the deficiency of skeletal balance, shortly after acute oestrogen deficiency. The changes in bone remodelling are accompanied by an increase in serum calcium while serum immunoreactive parathyroid hormone levels remain unchanged or even decrease, suggesting a shift to right of the parathyroid gland set-point. The reasons for the negative skeletal balance after oophorectomy might be sought therefore at bone tissue level, even if changes in responsiveness and/or of the parathyroid gland set-point could also be contributory.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
