Chronic morphine administration causes a 40% reduction of 3H-labeled 5-hydroxytryptamine (5-HT) binding in the brain stems of dependent rats, with little or no effect in other brain regions. Binding of [ 3H]dihydroalprenolol, 2,2,6-[ 3H]dimethoxyphenoxy-(ethylaminomethyl)benzodioxan, and [ 3H]spiroperidol is not affected by this treatment. The specificity of the reduction in 5-HT receptor number in the brain stem is discussed in terms of persistent activation of central 5-HT neurons by long-term treatment with morphine.

Changes in serotonin, but not catecholamine, receptor binding in the brain of morphine-dependent rats / T., Mennini; E., Poggesi; S., Cotecchia; DE BLASI, Antonio; R., Samanin. - In: MOLECULAR PHARMACOLOGY. - ISSN 0026-895X. - STAMPA. - 20:2(1981), pp. 237-239.

Changes in serotonin, but not catecholamine, receptor binding in the brain of morphine-dependent rats

DE BLASI, ANTONIO;
1981

Abstract

Chronic morphine administration causes a 40% reduction of 3H-labeled 5-hydroxytryptamine (5-HT) binding in the brain stems of dependent rats, with little or no effect in other brain regions. Binding of [ 3H]dihydroalprenolol, 2,2,6-[ 3H]dimethoxyphenoxy-(ethylaminomethyl)benzodioxan, and [ 3H]spiroperidol is not affected by this treatment. The specificity of the reduction in 5-HT receptor number in the brain stem is discussed in terms of persistent activation of central 5-HT neurons by long-term treatment with morphine.
1981
01 Pubblicazione su rivista::01a Articolo in rivista
Changes in serotonin, but not catecholamine, receptor binding in the brain of morphine-dependent rats / T., Mennini; E., Poggesi; S., Cotecchia; DE BLASI, Antonio; R., Samanin. - In: MOLECULAR PHARMACOLOGY. - ISSN 0026-895X. - STAMPA. - 20:2(1981), pp. 237-239.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/453577
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