In aged rats (21-23 vs 3 month) the neuroleptic receptor number was reduced in the striatum (--53%), in the limbic area (--36%), and not changed in the cortex. The in vitro pharmacological profile of the remaining [3H]spiroperidol receptors in each area was not modified in aged animals. The binding of [3H]ADTN (2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronapthalene) in the striatum and of [3H]serotonin ([3H]-5 HT) in the cortex was also the same in both age groups.
Selective reduction of one class of dopamine receptor binding sites in the corpus striatum of aged rats / DE BLASI, Antonio; Mennini, T.. - In: BRAIN RESEARCH. - ISSN 0006-8993. - STAMPA. - 242:(1982), pp. 361-364.
Selective reduction of one class of dopamine receptor binding sites in the corpus striatum of aged rats.
DE BLASI, ANTONIO;
1982
Abstract
In aged rats (21-23 vs 3 month) the neuroleptic receptor number was reduced in the striatum (--53%), in the limbic area (--36%), and not changed in the cortex. The in vitro pharmacological profile of the remaining [3H]spiroperidol receptors in each area was not modified in aged animals. The binding of [3H]ADTN (2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronapthalene) in the striatum and of [3H]serotonin ([3H]-5 HT) in the cortex was also the same in both age groups.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
