Sulfinpyrazone increased the number of beta-adrenoceptors (+ 17-40%) on intact human lymphocytes at concentrations ranging from 10(-5) to 2 X 10(-4) M. It affected the Bmax (187 +/- 6 and 142 +/- 5 fmol mg-1 protein respectively with and without sulfinpyrazone, P less than 0.001) but did not influence KD (4.4 +/- 0.3 and 4.6 +/- 0.7 nM with and without the drug). This effect was observed on either washed or unwashed lymphocyte membrane preparations. These findings have several pharmacological and therapeutic implications.
Sulfinpyrazone increases the number of beta-adrenoceptors on intact human lymphocytes / DE BLASI, Antonio; C., Costantini. - In: JOURNAL OF PHARMACY AND PHARMACOLOGY. - ISSN 0022-3573. - STAMPA. - 36:9(1984), pp. 630-632.
Sulfinpyrazone increases the number of beta-adrenoceptors on intact human lymphocytes.
DE BLASI, ANTONIO;
1984
Abstract
Sulfinpyrazone increased the number of beta-adrenoceptors (+ 17-40%) on intact human lymphocytes at concentrations ranging from 10(-5) to 2 X 10(-4) M. It affected the Bmax (187 +/- 6 and 142 +/- 5 fmol mg-1 protein respectively with and without sulfinpyrazone, P less than 0.001) but did not influence KD (4.4 +/- 0.3 and 4.6 +/- 0.7 nM with and without the drug). This effect was observed on either washed or unwashed lymphocyte membrane preparations. These findings have several pharmacological and therapeutic implications.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
