MODalign is an interactive web-based tool aimed at helping protein structure modelers to inspect and manually modify the alignment between the sequences of a target protein and of its template(s). It interactively computes, displays and, upon modification of the target-template alignment, updates the multiple sequence alignments of the two protein families, their conservation score, secondary structure and solvent accessibility values, and local quality scores of the implied three-dimensional model(s). Although it has been designed to simplify the target-template alignment step in modeling, it is suitable for all cases where a sequence alignment needs to be inspected in the context of other biological information.
Improving your target-template alignment with MODalign / Barbato, Alessandro; P., Benkert; T., Schwede; Tramontano, Anna; Kosinski, Jan. - In: BIOINFORMATICS. - ISSN 1367-4803. - 28:7(2012), pp. 1038-1039. [10.1093/bioinformatics/bts070]
Improving your target-template alignment with MODalign
BARBATO, ALESSANDRO;TRAMONTANO, ANNA;KOSINSKI, JAN
2012
Abstract
MODalign is an interactive web-based tool aimed at helping protein structure modelers to inspect and manually modify the alignment between the sequences of a target protein and of its template(s). It interactively computes, displays and, upon modification of the target-template alignment, updates the multiple sequence alignments of the two protein families, their conservation score, secondary structure and solvent accessibility values, and local quality scores of the implied three-dimensional model(s). Although it has been designed to simplify the target-template alignment step in modeling, it is suitable for all cases where a sequence alignment needs to be inspected in the context of other biological information.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.