The effects of cathinone (active principle of Khat), on in vivo and in vitro lipolysis in rats have been studied. In vivo cathinone induces lipolytic activity, which is inhibited by reserpinization. In isolated adipocytes cathinone is devoid of intrinsic activity but does inhibit norepinephrine-induced Free Fatty Acids (FFA) release and cyclic AMP (cAMP) accumulation. Indirect lipolytic action, similar to that of amphetamines, is discussed.
Cathinone, active principle of the Khat leaf: Its effects on in vivo and in vitro lipolysis / Nencini, Paolo. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - 12:9(1980), pp. 855-861.
Cathinone, active principle of the Khat leaf: Its effects on in vivo and in vitro lipolysis
NENCINI, Paolo
1980
Abstract
The effects of cathinone (active principle of Khat), on in vivo and in vitro lipolysis in rats have been studied. In vivo cathinone induces lipolytic activity, which is inhibited by reserpinization. In isolated adipocytes cathinone is devoid of intrinsic activity but does inhibit norepinephrine-induced Free Fatty Acids (FFA) release and cyclic AMP (cAMP) accumulation. Indirect lipolytic action, similar to that of amphetamines, is discussed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
