Met-enkephalin and Leu-enkephalin lipolytic activity in human omental adipose tissue is compared with that of morphine, methadone and naloxone. Met- and leu-enkephalin exhibited lipolytic action similar to that of morphine but unlike that of methadone. Naloxone, which was devoid of lipolytic activity, partially inhibited enkephalin-induced free fatty acids (FFA) release and slghtly increased morphine-induced FFA release. Naloxone and morphine inhibited epinephrine-stimulated lipolysis but methadone did not. The possibility that a non-opiate peptidergic receptor mediate opioid and opiate activity in human adipose tissue is suggested.
The lipolytic activity of met-enkephalin, leu-enkephalin, morphine, methadone and naloxone in human adipose tissue / Nencini, P., Paroli, E.. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - 13:6(1981), pp. 535-540.
The lipolytic activity of met-enkephalin, leu-enkephalin, morphine, methadone and naloxone in human adipose tissue
NENCINI, Paolo;PAROLI, Eugenio
1981
Abstract
Met-enkephalin and Leu-enkephalin lipolytic activity in human omental adipose tissue is compared with that of morphine, methadone and naloxone. Met- and leu-enkephalin exhibited lipolytic action similar to that of morphine but unlike that of methadone. Naloxone, which was devoid of lipolytic activity, partially inhibited enkephalin-induced free fatty acids (FFA) release and slghtly increased morphine-induced FFA release. Naloxone and morphine inhibited epinephrine-stimulated lipolysis but methadone did not. The possibility that a non-opiate peptidergic receptor mediate opioid and opiate activity in human adipose tissue is suggested.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
