In order to study the pharmacodynamic basis of therapeutic uses of placental extracts, research was carried out on Sephadex G25 fractions of autolytic extract of human placenta. Four of these fractions showed immunoreactivity for both β-endorphin and ACTH, and were able to stimulate lipolysis in rabbit adipose tissue. An inhibition of the enkephalinase activity of rat brain homogenates was displayed by placental fractions of low molecular weight. These results suggest that β-endorphin and ACTH play a role in the pharmacological activity of placental extracts.
Lipolytic and enkephalinase inhibitory activities of polypeptides from placental autolysate prepared for therapeutic purposes / Nencini, Paolo; Paroli, Eugenio. - In: INTERNATIONAL JOURNAL OF TISSUE REACTIONS. - ISSN 0250-0868. - 3:3-4(1981), pp. 167-172.
Lipolytic and enkephalinase inhibitory activities of polypeptides from placental autolysate prepared for therapeutic purposes
NENCINI, Paolo;PAROLI, Eugenio
1981
Abstract
In order to study the pharmacodynamic basis of therapeutic uses of placental extracts, research was carried out on Sephadex G25 fractions of autolytic extract of human placenta. Four of these fractions showed immunoreactivity for both β-endorphin and ACTH, and were able to stimulate lipolysis in rabbit adipose tissue. An inhibition of the enkephalinase activity of rat brain homogenates was displayed by placental fractions of low molecular weight. These results suggest that β-endorphin and ACTH play a role in the pharmacological activity of placental extracts.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
