A case of lefetamine abuse (0.9-1.8 g/day in 15-30 i.m. divided doses) is reported. In this patient, the administration of naloxone precipitated a mild opiate-like withdrawal syndrome, characterized by mydriasis, piloerection, yawning and a slight increase of blood pressure. The complete withdrawal of lefetamine, substituted by a placebo regimen, aggravated these symptoms. Furthermore, experimental results showed that lefetamine induced a naloxone-reversible inhibition of the guinea-pig ileum contractile response to electric field stimulation, and that naloxone pretreatment of mice prevented lefetamine antinociceptive activity in the hot-plate test. The clinical and experimental findings suggest that lefetamine has an opiate-like activity.
Clinical and experimental evidence of an opiate-like activity of lefetamine / Paroli, Eugenio; Nencini, Paolo; M., Moscucci. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - 16(1984), pp. 915-922.
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Titolo: | Clinical and experimental evidence of an opiate-like activity of lefetamine. | |
Autori: | ||
Data di pubblicazione: | 1984 | |
Rivista: | ||
Citazione: | Clinical and experimental evidence of an opiate-like activity of lefetamine / Paroli, Eugenio; Nencini, Paolo; M., Moscucci. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - 16(1984), pp. 915-922. | |
Handle: | http://hdl.handle.net/11573/452722 | |
Appartiene alla tipologia: | 01a Articolo in rivista |