1. To examine whether the hyperdipsic response to chronic administration of d,l-amphetamine (AMPH) is associated with modification of salt appetite, rats were allowed to choose between tap water and a 1.7% NaCl solution. 2. Under AMPH rats preferred water to saline throughout the experiment. 3. By testing rats in a distinct test cage environmental influences on AMPH-mediated hyperdipsia were also evaluated. 4. In the test cage hyperdipsia was suppressed, but preference for tap water was preserved. 5. Finally, the role of alpha(2)-adrenoceptors in the drinking response to AMPH was evaluated by studying the effects of clonidine and yohimbine on water intake. 6. We conclude that AMPH-induced preference for tap water over saline is unrelated to hyperdipsia but, being also induced by yohimbine, it may depend on noradrenergic mechanisms.
PHYSIOLOGICAL AND ENVIRONMENTAL ASPECTS OF DRINKING STIMULATED BY CHRONIC EXPOSURE TO AMPHETAMINE IN RATS / Stefano, Camanni; Nencini, Paolo. - In: GENERAL PHARMACOLOGY. - ISSN 0306-3623. - STAMPA. - 25:1(1994), pp. 7-13. [10.1016/0306-3623(94)90003-5]
PHYSIOLOGICAL AND ENVIRONMENTAL ASPECTS OF DRINKING STIMULATED BY CHRONIC EXPOSURE TO AMPHETAMINE IN RATS
NENCINI, Paolo
1994
Abstract
1. To examine whether the hyperdipsic response to chronic administration of d,l-amphetamine (AMPH) is associated with modification of salt appetite, rats were allowed to choose between tap water and a 1.7% NaCl solution. 2. Under AMPH rats preferred water to saline throughout the experiment. 3. By testing rats in a distinct test cage environmental influences on AMPH-mediated hyperdipsia were also evaluated. 4. In the test cage hyperdipsia was suppressed, but preference for tap water was preserved. 5. Finally, the role of alpha(2)-adrenoceptors in the drinking response to AMPH was evaluated by studying the effects of clonidine and yohimbine on water intake. 6. We conclude that AMPH-induced preference for tap water over saline is unrelated to hyperdipsia but, being also induced by yohimbine, it may depend on noradrenergic mechanisms.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.