Pretreatment with naltrexone (2.5 and 5 mg/kg) prevented the decrease of 3-methoxytyramine (3-MT)/dopamine (DA) ratio induced by 2 h immobilization stress in the nucleus accumbens (NAS) of the mouse while it did not affect the stress-induced decrease of 3-MT/DA ratio in caudatus putamen (CP). Naltrexone also produced a slight antagonism of homovanillic acid (HVA)/DA ratio increase produced by stress in the frontal cortex (FC). These results point to an involvement of endogenous opioids in the effects of stress on DA metabolism in the mesolimbic system of the mouse.
STRESS-INDUCED DECREASE OF 3-METHOXYTYRAMINE IN THE NUCLEUS ACCUMBENS OF THE MOUSE IS PREVENTED BY NALTREXONE PRETREATMENT / Cabib, Simona; Oliverio, Alberto; PUGLISI ALLEGRA, Stefano. - In: LIFE SCIENCES. - ISSN 0024-3205. - STAMPA. - 45:12(1989), pp. 1031-1037. [10.1016/0024-3205(89)90159-8]
STRESS-INDUCED DECREASE OF 3-METHOXYTYRAMINE IN THE NUCLEUS ACCUMBENS OF THE MOUSE IS PREVENTED BY NALTREXONE PRETREATMENT
CABIB, Simona;OLIVERIO, Alberto;PUGLISI ALLEGRA, Stefano
1989
Abstract
Pretreatment with naltrexone (2.5 and 5 mg/kg) prevented the decrease of 3-methoxytyramine (3-MT)/dopamine (DA) ratio induced by 2 h immobilization stress in the nucleus accumbens (NAS) of the mouse while it did not affect the stress-induced decrease of 3-MT/DA ratio in caudatus putamen (CP). Naltrexone also produced a slight antagonism of homovanillic acid (HVA)/DA ratio increase produced by stress in the frontal cortex (FC). These results point to an involvement of endogenous opioids in the effects of stress on DA metabolism in the mesolimbic system of the mouse.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
