Influence of monoclonal antibodies against HLA class I and class II antigen on interferon-gamma and -alpha induction.

Ausiello, C; Spagnoli, Gc; Antonelli, Guido; Malavasi, F; Casciani, Cu; Dianzani, F.

doi:10.1089/jir.1987.7.133

The effects of several monoclonal antibodies (MAbs) directed against different epitopes of HLA class I and class II antigens on interferon (IFN)-gamma and IFN-alpha production were studied. The results indicate that: these MAbs have a marked inhibitory effect on the production of IFN-gamma induced by alloantigens and microbial antigens; they influence only to a lesser extent staphylococcal enterotoxin B (SEB)- and phytohemagglutinin (PHA)-induced IFN-gamma production; such effects parallel inhibition of lymphoproliferation except for PHA-induced blastogenesis, which is not affected; on the other hand, these MAbs have no effect on the production of IFN-alpha induced by lipopolysaccharide (LPS) or viruses.

Influence of monoclonal antibodies against HLA class I and class II antigen on interferon-gamma and -alpha induction / Ausiello, C; Spagnoli, Gc; Antonelli, Guido; Malavasi, F; Casciani, Cu; Dianzani, F.. - In: JOURNAL OF INTERFERON RESEARCH. - ISSN 0197-8357. - STAMPA. - 7(1987), pp. 133-143. [10.1089/jir.1987.7.133]

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Titolo:	Influence of monoclonal antibodies against HLA class I and class II antigen on interferon-gamma and -alpha induction.
Autori:	Ausiello C Spagnoli GC ANTONELLI, Guido Malavasi F Casciani CU Dianzani F. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1987
Rivista:	JOURNAL OF INTERFERON RESEARCH
Citazione:	Influence of monoclonal antibodies against HLA class I and class II antigen on interferon-gamma and -alpha induction / Ausiello, C; Spagnoli, Gc; Antonelli, Guido; Malavasi, F; Casciani, Cu; Dianzani, F.. - In: JOURNAL OF INTERFERON RESEARCH. - ISSN 0197-8357. - STAMPA. - 7(1987), pp. 133-143. [10.1089/jir.1987.7.133]
Handle:	http://hdl.handle.net/11573/452132
Appartiene alla tipologia:	01a Articolo in rivista

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