Administration of naloxone or naltrexone in DBA/2 (DBA) mice was followed by dose related depressant effects. The locomotor activity of the C57L/6 (C57) mice injected with naltrexone was also depressed. Low doses of naloxone induced a decrease in activity in the C57 strain. This effect gradually disappeared at intermediate doses and recurred again at higher doses. The results are discussed in terms of differences in type number and/or distribution of the receptors influenced by naloxone and naltrexone in the two strains of mice tested.
Effects of naloxone and naltrexone on locomotor activity in C57BL/6 and DBA/2 mice / C., Castellano; PUGLISI ALLEGRA, Stefano. - In: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. - ISSN 0091-3057. - STAMPA. - 16:4(1982), pp. 561-563.
Effects of naloxone and naltrexone on locomotor activity in C57BL/6 and DBA/2 mice
PUGLISI ALLEGRA, Stefano
1982
Abstract
Administration of naloxone or naltrexone in DBA/2 (DBA) mice was followed by dose related depressant effects. The locomotor activity of the C57L/6 (C57) mice injected with naltrexone was also depressed. Low doses of naloxone induced a decrease in activity in the C57 strain. This effect gradually disappeared at intermediate doses and recurred again at higher doses. The results are discussed in terms of differences in type number and/or distribution of the receptors influenced by naloxone and naltrexone in the two strains of mice tested.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
