Electroconvulsive shock (ECS)-induced seizures present a clear cut diurnal rhythmicity when BALB/c mice are subjected to a light-dark (L/D) schedule. On the contrary, in the absence of external synchronizers no evident fluctuations in epileptic behaviour were evident. Naloxone decreased the threshold of ECS-induced convulsions, thus confirming an involvement of opioids in this type of behaviour. These findings indicate that opioids present a diurnal (L/D) but not circadian (L/L) rhythmicity in BALB/c mice.
Diurnal variations in electroconvulsive shock-induced seizures: involvement of endogenous opioids / Oliverio, Alberto; C., Castellano; PUGLISI ALLEGRA, Stefano; Renzi, Paolo. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - STAMPA. - 57:(1985), pp. 237-240. [10.1016/0304-3940(85)90497-5]
Diurnal variations in electroconvulsive shock-induced seizures: involvement of endogenous opioids.
OLIVERIO, Alberto;PUGLISI ALLEGRA, Stefano;RENZI, Paolo
1985
Abstract
Electroconvulsive shock (ECS)-induced seizures present a clear cut diurnal rhythmicity when BALB/c mice are subjected to a light-dark (L/D) schedule. On the contrary, in the absence of external synchronizers no evident fluctuations in epileptic behaviour were evident. Naloxone decreased the threshold of ECS-induced convulsions, thus confirming an involvement of opioids in this type of behaviour. These findings indicate that opioids present a diurnal (L/D) but not circadian (L/L) rhythmicity in BALB/c mice.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
