After repeated stressful experiences, DBA/2 (DBA) mice showed an increase in apomorphine-induced climbing while C57BL/6 (C57) mice showed a clear-cut decrease of this behavior. Genetic analysis involving F1 and F2 hybrids and the backcross populations (F1 X C57; F1 X DBA) indicated complete dominance of the C57 genotype and a significant genotype X environment interaction. These findings are discussed in terms of dopaminergic plasticity and of the heuristic value of this animal model in relation to disturbed behaviors triggered by stressful experiences.
A genetic analysis of stereotypy in the mouse: dopaminergic plasticity following chronic stress / Cabib, Simona; PUGLISI ALLEGRA, Stefano; A., Oliverio. - In: BEHAVIORAL AND NEURAL BIOLOGY. - ISSN 0163-1047. - 44:(1985), pp. 239-248. [10.1016/S0163-1047(85)90254-7]
A genetic analysis of stereotypy in the mouse: dopaminergic plasticity following chronic stress.
CABIB, Simona;PUGLISI ALLEGRA, Stefano;
1985
Abstract
After repeated stressful experiences, DBA/2 (DBA) mice showed an increase in apomorphine-induced climbing while C57BL/6 (C57) mice showed a clear-cut decrease of this behavior. Genetic analysis involving F1 and F2 hybrids and the backcross populations (F1 X C57; F1 X DBA) indicated complete dominance of the C57 genotype and a significant genotype X environment interaction. These findings are discussed in terms of dopaminergic plasticity and of the heuristic value of this animal model in relation to disturbed behaviors triggered by stressful experiences.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
