Post-training administration of the selective D1 or D2 agonists SKF 38393 and LY 171555 dose dependently impairs retention of an inhibitory avoidance response in DBA/2 mice. In agreement, the selective D1 or D2 antagonists SCH 23390 and (-)-sulpiride improve retention. These effects are opposite to those observed in the C57BL/6 strain, as previously reported. Moreover, B6D2F1 hybrids present a response to SKF 38393, LY 171555, SCH 23390, and (- )-sulpiride that parallels that of the C57BL/6 strain, thus suggesting that the neural mechanisms underlying the effects of DA agonists or antagonists on memory processes may be inherited through a dominant mode of inheritance.
STRAIN-DEPENDENT EFFECTS OF POST-TRAINING DOPAMINE RECEPTOR AGONISTS AND ANTAGONISTS ON MEMORY STORAGE IN MICE / Cestari, Vincenzo; Claudio, Castellano; Cabib, Simona; PUGLISI ALLEGRA, Stefano. - In: BEHAVIORAL AND NEURAL BIOLOGY. - ISSN 0163-1047. - STAMPA. - 58:1(1992), pp. 58-63. [10.1016/0163-1047(92)90922-q]
STRAIN-DEPENDENT EFFECTS OF POST-TRAINING DOPAMINE RECEPTOR AGONISTS AND ANTAGONISTS ON MEMORY STORAGE IN MICE
CESTARI, VINCENZO;CABIB, Simona;PUGLISI ALLEGRA, Stefano
1992
Abstract
Post-training administration of the selective D1 or D2 agonists SKF 38393 and LY 171555 dose dependently impairs retention of an inhibitory avoidance response in DBA/2 mice. In agreement, the selective D1 or D2 antagonists SCH 23390 and (-)-sulpiride improve retention. These effects are opposite to those observed in the C57BL/6 strain, as previously reported. Moreover, B6D2F1 hybrids present a response to SKF 38393, LY 171555, SCH 23390, and (- )-sulpiride that parallels that of the C57BL/6 strain, thus suggesting that the neural mechanisms underlying the effects of DA agonists or antagonists on memory processes may be inherited through a dominant mode of inheritance.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
